Research


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Research project (§ 26 & § 27)
Duration : 2017-11-01 - 2019-10-31

The project aims to develop novel bio-based technologies for the selective separation and recovery of synthetic textile fibers for recycling in the textile industry. This is based on the use of enzymes that can metabolize or degrade highly specific macromolecules. While the degradation of cellulose by enzymes has been studied in nature for 150 years and has also been used for decades for engineering applications, enzymes that are also able to metabolize synthetic fibers have been developed quite recently. Due to the high specificity of these enzymes, it is possible to gradually "extract" valuable components from textile residual flows of multi-material composition and / or to recycle certain fibers by systematic and gentle separation of unwanted fibers.
Research project (§ 26 & § 27)
Duration : 2017-10-01 - 2020-09-30

Rheumatoid arthritis (RA) is affecting the global population. This chronic disease can lead to serious joint damages and disabilities caused by prolonged inflammatory states with a duration from weeks to years. During these inflammatory states macrophages are playing a key role as possible distinctive markers of activation and maturation while folatereceptor beta expression rates are selectively elevated in RA synovial macrophages. Its high affinity for folic acid (FA) can be used as a strategy for targeted drug delivery to chronically activated macrophages by binding FA on the delivery particle. In this way severe side effects occurring with currently used RA treatment methods, which can be avoided by site specific drug delivery and reduced drug loading. Furthermore, decreases in the pH-value in inflammatory and cancerous tissue from pH 7.4 to pH 5.4 are reported and could serve as an additional target for a stimuli-responsive treatment strategy. Therefore, the aim of this project is the development of a bifunctional nanoparticle system for a new RA treatment strategy. On the one hand a pH-depending release profile will enable drug release only in the acidic environment of inflamed tissue while on the other hand specific targeting to chronically activated macrophages will be achieved by surface functionalization with either FA or monoclonal antibodies (mAb). Based on research results of the last decade, human serum albumin (HSA), silk fibroin (SF) and silk-elastin like proteins (SELPs) could offer nanotechnological approaches for new stimuli-responsive treatment strategies with SF and SELPs adding stimuli-responsive properties to HSA based systems. In this project HSA/silk fibroin and HSA/SELPs combinations will be investigated regarding their nanoparticle formation ability, the pH-responsive drug release behaviour and in addition the cell toxicity using various analytical methods.
Research project (§ 26 & § 27)
Duration : 2017-10-01 - 2020-09-30

Increasing environmental pollution concerns linked to climate change, increasing number of chronic diseases as well as the diminishing supply of none renewable resources (e.g. the world's petroleum-based chemicals and materials) is directing efforts towards to development of green chemistry technologies, and efficient and maximum exploitation of renewable resources. Current biorefinery concepts focus on lignocellulosic biomass as a feedstock for the production of next generation biofuels and platform chemicals. Lignin a by-product of wood pulping process, is one of the major chemical constituents of woody biomass and second most abundant biopolymer on Earth, surpassed only by cellulose. Traditionally, lignin has been viewed as a waste material and burned as an inefficient fuel. However, in recent decades, research has focused on more economical ways to convert lignin into value-added commodities, such as biofuels, biomaterials, and biochemicals, thus developing and strengthening the concept of fully integrated biorefineries. In this study, we propose to adapt our previously developed novel laccase lignin polymerization system based on continuous supply of oxygen to produce versatile lignin based wood coating fromulations with enhanced adhesives, hydrophobic, antimicrobial, flame retardant and UV-stability property

Supervised Theses and Dissertations