Research


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Research project (§ 26 & § 27)
Duration : 2018-10-01 - 2022-09-30

Um die Potenziale der sich rasant entwickelnden Omics-Technologien und die Verarbeitung der damit verbundenen riesigen Datenmengen optimal erschliessen zu können, sind die Schaffung zusätzlicher Kompetenz auf dem Gebiet der Bioinformatik und die Entwicklung neuer Auswertealgorithmen unerlässlich. Ziel des vorliegenden Projekts ist es, die verschiedenen „Omics-Disziplinen“ (Genomik, Transkriptomik, Proteomik und Metabolomik) am Technopol Tulln zu vernetzen und die auf diesen Gebieten tätigen Wissenschaftler durch Aufbau einer Bioinformatik-Plattform zu unterstützen. Durch den Aufbau zusätzlicher Kompetenz und neuer innovativer Methoden soll so ein zusätzlicher Nutzen für die bereits auf hohem Niveau laufende Forschung erzielt werden. In diesem Projekt sollen neue Bioinformatik-Werkzeuge entwickelt und etabliert werden, die für viele (auch zukünftige) Fragestellungen in den Biowissenschaften eingesetzt werden können um den riesigen Umfang an Rohdaten zu reduzieren, statistisch auszuwerten und grafisch so aufzubereiten, dass diese für die weitere Interpretation zugänglich werden. Das Projekt ist in vier wissenschaftliche Module gegliedert. Um den angestrebten Nutzen zu maximieren werden die Bioinformatiker in bereits bestehende Forschungsprojekte im Bereich der Omics-Disziplinen eingebunden. Für das die sie allgemein einsetzbare, benutzerfreundliche Softwarelösungen für die Datenauswertung entwickeln sollen. Zusätzlich sollen die und in den jeweiligen Projekten auch die Prozessierung der Messdaten zu übernehmen und gezielt zu erweitern.
Research project (§ 26 & § 27)
Duration : 2018-09-01 - 2020-08-31

The biostability of water, i.e. the ability to store and distribute water without negative microbiological quality changes, is a crucial aspect in public water supply. Biostability is important for the esthetical characteristics of water (e.g. good taste and appearance) and it is essential to protect public health (i.e. conditions to not support the growth of facultative pathogens, such as Pseudomonas aeruginosa). The methods for the determination of biostability of water still suffer from major technical shortcomings and require significant future improvements. Due to a permanent increase of ground water temperature, caused by the global change (on average 0.05C° per year), growth of facultative pathogens is likely increasing in drinking water. The improved possibility to analyze and predict the growth potential of facultative pathogens in ground- and drinking water is thus becoming more important. This research project aims to develop and evaluate a new innovative approach to determine the biostability of ground- and drinking water by using up-to-date high-throughput DNA sequencing technology to screen and predict for bacterial population changes. To enable the tracking of biochemical key-processes in water supply, the possibility to combine the “basic module” with high-resolution chemical analysis will be determined as well. The main focus of AQUASCREEN is directed towards drinking water recourses which have significance in Lower Austria (i.e. well water, spring water, ground water).
Research project (§ 26 & § 27)
Duration : 2018-10-01 - 2025-09-30

The CD Laboratory for Innovative Gut Health Concepts of Livestock is divided into a main module at the University of Veterinary Medicine Vienna (CDL Head Prof. Quendrim Zebeli) and an external module at the IFA-Tulln of the BOKU. In this project, the factors influencing intestinal health in cattle and pigs are investigated. Special focus is on transition dairy cows and weaning piglets. The reasons for reduced intestinal health will be investigated, early indicators will be found and subsequently feed additives to prevent dysbiosis will be developed and tested. The external module represents a metabolomics platform to answer the questions of the project. In particular, biomarkers that provide information on intestinal health are to be found. The tasks of the external module include the development, validation and application of methods based on high-performance liquid chromatography - mass spectrometry for the determination of over 300 metabolites of the primary metabolism in various animal matrices such as rumen fluid, urine, faeces, blood, saliva and milk. In addition to targeted metabolomics analysis, non-targeted metabolomics workflows will be developed and subsequently tested for their robustness to discover new biomarkers. Furthermore, an in-house database with the compounds of the bovine and porcine metabolome is to be created. Different isotope labeling techniques such as the differential isotope labeling technique will be developed for the targeted derivatisation of compounds with specific functional groups to detect differences in the metabolome of sick and healthy animals or differently fed/treated animals. Finally, the most appropriate biomarker-matrix combinations will be used to test the efficiency of feed additives to maintain intestinal health in transitional dairy cows and weaning piglets.

Supervised Theses and Dissertations